Animal foodstuffs



, 2,925,341 My l atented Feb -16, 1960 l Kurt Kaemmerer, Wupperta signor to Farbenfabriken Bayer fiktiengesellschaft rkus m' rman a surrender of G y No Drawing. Applicatio 'January, .;'Serial'No;1637-,-370- Claims priority, application'Germany '4, 3 Claims. (Cl. 99-2 This invention relates tofeeds for animals and more particularly it relates to a feed supplement containing auxines, heteroauxines or calines.

For some years there has been extensive study of the need for various nutrients in feed for poultry and livestock. This study has resulted in the evolution of feeds compounded to include all of the ingredients necessary to provide the proper proportions of materials such as, for example, proteins, carbohydrates, minerals, vitamins, etc.as well as the formulation of rations designed for specific feeding purposes. Following the development of rations balanced in essential nutrients, it was found that other substances could beincluded in: the ration which would serve as growth promoters and increase the rate at which livestock developed, resulting in a larger animal at an earlier age. Growth promoters commonly employed by feed manufacturers include. vitamin'B animal protein factor, commonly referred to as APF, etc. Recently it has been found-thatthe inclusion of certain antibiotics such as bacitracin, penicillin, oxytetracyclin or chlortetracyclin in feed supplements acts to give an additional growth promoting effect and aids in producing larger animals at an earlier age than can be done with;

feeds containing only the vitamin B of APF as supplements.

We have now discovered that certain auxines, heteroauxines or calines constitute a new growth-promoting feed supplement of superior efficiency in its'growthpromoting effect. Their use enables'the production of larger animals in a shorter time than heretofore achieved. Additionally these growth-promoting supplements permit considerable savings of other nutrients in the feed of cattle and other livestock, chickens and other poultry.

The invention is a feed supplement containing as its essential active ingredients such auxines, heteroauxines and compounds of the bios-group like the biotin known as vitamin H, which have a specific activity on the multiplication and the growth of the cells of plants. Such compounds are for instance: oz-l'lElPhthYl acetic acid and its salts, Z-methyl-chloro-phenoxy acetic acid and its salts, 2,4-dichloro-phenoxy acetic acid and its salts, 4-phenyl acetic acid and its salts, further fY-indolyl acetic acid and tive ingredients contained in animalfeed according to it being limited thereto. V I

Example 1 The addition of the auxines to the animal feed permits to favorably .influence the paunch flora of ruminantsand the ch1ckens have a smaller feed consumption.

percent percent improveimprove- V peraverage ;ment of merit in 1 cent weight increase feed.- active ingredient in increase in comutilization V feed inside parison for 100 4 weeks with grams in No. 7 comparison with N o. 7

(1) sodium-a-naphthyl 0.001 423 74.8 -28.2

- acetate. (2). sodium-2-methyl-4- 0. 001 414 71. 1 24. 9

' chloro acetate. (3). 2,4-dichlorophenoxy 0.001 432 78.5 31.3

acetic acid. (4) sodium phenyl 0.005 I 430 77.7 28.5

acetate. (5) indolyl acetic acid-.- 0.001 433 78.9 29.1 (6 control 0 348 43.8 21.4 (7). control deficiently 0 242 0 0 r fed with animal 7 protein.

This table shows the action of the feed supplements in phenoxy acetic acid and their salts. The amounts of ac- I to stimulate an increased protein production. This can I be established by the fermentation process in the artificial paunch. The following table shows the range of activity ncrease of protein formation j in percent. per-125' "without with ml. ml. growth. .'.pro-.. A meter nhth Q1 .v 1. L '2 i (2) sodium-2-methyl-4- 1-60 25 +465 chloro-phenoxy acetate. (3) 2,4-dichlorophenoxy 1:40 30 100 +542 acetic acid. (4). sodiumphenyl 1-50 20 100 +230 acetate. (5)...- B-indolyl acetic 0.1-20 1 100- +393 acid.

Example 2 In a poultry feed used for the raising of chickens small amounts of auxines are added. It is found that the chickens show improved growth response inside the same perriod of feeding compared with the controls which have been fed without these supplements. At the same time the raising of chickens. The basic feed contains 16.3% of total protein, 2% of animal protein, 70.4% o'f'total nutrients. Group 7 obtained a deficient feed of 16.44% of total proteins without animal protein and a total nutrient amount'of 70.6%. The average starting weight of the chickens was 112 grams.

Example 3 During the raising of chickens the feed was supplemented by the addition of 0.002-0.004% of sodium-phenoxy acetate. In the same period of feeding higherweight increase and an improved utilisation of thefeed was achieved in comparison with the controls.

percent additional percent g concentrar" 1 of weight I of imtion of the weight increase proved active ingredient active 7 increase compared feed ingredient in4 with the utilisain percent weeks in controls tion grams. in percent.

(1) sodium- 0.002 285.7 +11.3 +5.4

' phenoxy x acetate. i (2) sodium- 0.004 311.6 +21;5 +5.9

' phenoxy V v acetate. 1

(3)..-. control 256.59

The starting weight of thechickens was 121 grams per 1. A livestock feed comprisingja nutrientlteed.mixed with an amount of an auxine selected from the group consisting of d-naplithyl acetic acid, 2-nietliyl 4-chloro phenoxy acetic acid, phenoxy acetic acid, indolyl acetic 7 acid and their salts, sufiicient-to produce therehy a positive growth-promoting effect and being less than a toxic amount.

2. A livestock feed conipris'ing a nutrient feed mixed with from about 00005 toabout 01005 herce'nt of'an auxine selected from the group consisting of -naphtliyl' acetic I a n acid, 2-rnethyl-4-chloro-phenoxy acetic acid, 2,4 dichlorophenoxy acetic acid, phenoxy acetic acid, indolyl acetic acid and their salts.

3. A livestock feed comprising a nutrient feed mixed with from about 0.001 toabout 0.005 percent of an auxine selected from the group consisting of a-naphthyl acetic acid, 2-methyl-4 chloro phenoxy acetic acid, 2,4-dichlorophenoxy acetic acid, phenqxy acetic acid, indolyl acetic 'acidfandtheir salts. I h

References Cited the file ofthispaten Chem.Abst. 45: 228H.l 1 1 Rowe et al.: American I. of Veterinary Research, vol.

UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent Non 2-, 925 34l February 16 1960 Kurt Kaemmerer It is hereby certified that error appears in the printed specification of the above numbered patent requiring correction and that the said Letters Patent should readas corrected below.

Column 2 line 4.6 for "16.3%? read 16,63 "a Signed and sealed this 23rd day of August 1960.

(saw Attest:

KARL H, AXLINE Attesting Oflicer ROBERT C. WATSO N Commissioner of Patents 

1. A LIVESTOCK FEED COMPRISING A NUTRIENT FEED MIXED WITH AN AMOUNT OF AN AUXINE SELECTED FROM THE GROUP CONSISTING OF A-NAPHTHYL ACETIC ACID, 2-METHYL-4-CHLORO PHENOXY ACETIC ACID, PHENOXY ACETIC ACID, INDOLYL ACETIC ACID AND THEIR SALTS, SUFFICIENT TO PRODUCE THEREBY A POSITIVE GROWTH-PROMOTING EFFECT AND BEING LESS THAN A TOXIC AMOUNT. 